Sugar acids and derivatives
TARGETMOL CHEMICALS INC Terrestrosin D 10MG
Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of terrestrosin D. Purity 99.54%
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Medchemexpress LLC Beta-Acetoxyisovalerylshikonin | 69091-17-4 | 25 MG
Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma.
- High purity: 99.57%
- Molecular weight: 430.45
- Molecular formula: C23H26O8
- Appearance: Brown to black solid
- Used in simultaneous densitometric determination of related compounds
- Applied in isolation and purification processes using preparative HPLC
Alkali Scientific 4 Methylumbelliferyl β L Fucopyranoside, 100 Milligrams
Methylumbelliferyl Fucopyranoside is a high-purity reagent used in biochemical analysis to evaluate the activity of enzymes that hydrolyze fucose-containing substrates. This 100mg preparation is useful in enzyme assays aimed at studying fucosidases, which play a key role in glycosylation and glycosaminoglycan metabolism. It is commonly used in research on carbohydrate metabolism, specifically in glycosyltransferase assays and enzyme-linked tests. Methylumbelliferyl Fucopyranoside is an essential reagent for labs studying the biochemical pathways of fucose and its role in both plant and animal systems.
Medchemexpress LLC Integrin alpha 8 bet 5ug
Integrin -8/ -1 coordinates the recruitment of mesenchymal cells during renal organogenesis and recognizes RGD sequences in ligands such as TNC FN1 SPP1 TGFB1 TGFB3 and VTN It plays a role in multiple cellular interactions critical for organogenesis including NPNT as a functional ligand in nephrogenesis Integrin alpha 8 beta 1 Protein Human (HEK293 His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein expressed by HEK293 with C-His labeled tag Integrin alpha 8 beta 1 Protein Human (HEK293 His) has molecular weight of 120-140 kDa 100-120 kDa respectively
Medchemexpress LLC Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- | 838810-96-1 | 98.0% | 25 MG
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). It demonstrates strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) and functions as an antivirulence agent, effectively reversing β-lactam resistance in Methicillin-resistant strains (MRSA).
- Potent synergism with cefuroxime
- Reduces β-lactam MIC against S. aureus USA300
- Enhances activity against S. aureus clinical isolates
- Potentiates effects against various circulating MRSA strains
- Synergizes with antimicrobial peptides colistin and polymyxin B
- Inhibits mprF expression
- Inhibits citrate-induced biofilm formation
- Effective as monotherapy for MRSA-infected larvae
- Increases survival in drug-treated larvae
- Correlates with concentration-dependent bacterial killing
Medchemexpress LLC Protac α-synuclein degrader 5 | 2781922-42-5 | 100.0% | 767.78 g/mol | C39H41N7O10 | 10 MG
PROTAC α-synuclein degrader 5 is a small-molecule PROTAC designed to selectively target and promote degradation of α-synuclein aggregates in cellular models. Supplied as a high-purity solid for preclinical research, it shows dose-dependent activity in fibril-seeding assays and is formulated for in vitro and in vivo use.
- Selective degradation of α-synuclein aggregates (DC50 ≈ 7.5 μM, Dmax 89%).
- Demonstrated reduction of aggregates within 48 hours in PFF seeding cell models.
- High-purity solid suitable for biochemical and cellular assays.
- High solubility in DMSO for in vitro applications (≥100 mg/mL).
- Compatible with in vivo formulation protocols and frozen storage for stability.
Medchemexpress LLC JBI-589 | 2308504-22-3 | 99.8% | 481.56 g·mol⁻¹ | C29H28FN5O | 10 MG
JBI-589 is a non-covalent, isoform-selective inhibitor of peptidylarginine deiminase 4 (PAD4) with oral bioavailability, developed for preclinical cancer and immunology research. It reduces CXCR2 expression, blocks neutrophil chemotaxis, and has shown activity in reducing primary tumor growth and metastasis in experimental studies.
- Selective PAD4 inhibition with demonstrated activity in cellular assays.
- Orally bioavailable small molecule suitable for in vivo studies.
- High chemical purity for research use.
- Soluble in DMSO at high concentrations (requires sonication).
- Stable when stored under recommended powder and solvent conditions.
Apexbio Technology LLC HMP Linker 68858-21-9 100g
HMP Linker is an acid-sensitive linker used in solid-phase peptide synthesis (SPPS) It is designed to facilitate the covalent attachment of peptide carboxy-terminal residues to solid-phase resin supports and enables controlled cleavage of synthesized peptides under mildly acidic conditions thereby preserving the structural integrity of sensitive functional groups and peptide termini HMP Linker acts primarily by hydrolyzing upon acid catalysis which allows the intact release of peptides from resin supports Based on these properties HMP Linker holds research potential in peptide therapeutics synthesis and studies requiring mild peptide cleavage conditions
![Alkali Scientific 4 Methylumbelliferyl α D Galactopyranoside Monohydrate [4 Methylumbelliferyl α D Galactoside], 100 Milligrams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000661164.jpg-250.jpg)
Alkali Scientific 4 Methylumbelliferyl α D Galactopyranoside Monohydrate [4 Methylumbelliferyl α D Galactoside], 100 Milligrams
Methylumbelliferyl Galactopyranoside is a high-purity reagent widely used in biochemical analysis, especially in assays targeting galactosidase enzymes. This 100mg reagent is commonly employed in studies of lactose metabolism and in enzymatic assays that involve the hydrolysis of galactose-containing substrates. It is especially useful in clinical research, microbiology, and biochemistry for studying the breakdown of complex carbohydrates. This reagent is essential in enzyme-linked assays, enzyme activity screening, and metabolic research focusing on galactose or lactose metabolism, providing valuable data on enzyme kinetics and activity.
Medchemexpress LLC 2-Naphthalenemethanol, decahydro-α,α,4a-trimethyl-8-methylene-, (2R,4aR,8aS)- | 473-15-4 | 25 MG
β-Eudesmol is a sesquiterpene-like compound extracted from the rhizome of *Atractylodes lancea*. It exhibits anticancer and anti-inflammatory activities, can induce apoptosis, and acts as a neostigmine antagonist, antagonizing neostigmine-induced neuromuscular failure. It is also utilized in sepsis disease studies.
- Exhibits anticancer activity
- Possesses anti-inflammatory effects
- Induces apoptosis
- Acts as a neostigmine antagonist
- Antagonizes neostigmine-induced neuromuscular failure
- Useful in sepsis disease studies
- Inhibits cell proliferation induced by VEGF and bFGF in HUVEC cells
- Reduces cell activity in HL-60 cells
- Activates caspase-3 by inducing cytochrome c release
- Inhibits tumor cell and new blood vessel generation in MK mice
- Inhibits the NF-κB signaling pathway
- Provides antioxidant effects
Apexbio Technology LLC HyperTrap Heparin FF Column 5x5ml
HyperTrap Heparin FF Column is an affinity chromatography medium designed for the purification of heparin-binding biomolecules The column exploits the strong ionic and specific interactions between immobilized heparin and target proteins such as growth factors coagulation factors and certain enzymes enabling selective retention and efficient separation from complex biological mixtures This tool is widely utilized in the isolation and characterization of heparin-binding proteins investigation of protein glycosaminoglycan interactions and purification of bioactive factors for downstream functional assays and structural analyses